I just thought you all should be aware of this KB Article at Symantec’s site:
Is VMware VMotion ESX server supported with Symantec AntiVirus and Symantec Endpoint Protection?
Symantec considers running Symantec AntiVirus Clients and Symantec Endpoint Protection Clients in VMware environments running Vmotion a supported configuration.
At this time running the Symantec Endpoint Manager (SEPM) is considered an alternative configuration and will be handled with “Best Effort Support”
Seems one has to be careful when using Endpoint Manager, but you should otherwise be fine.